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Keep an eye on Carefully (three)pentobarbital will reduce the extent or effect of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Potent or moderate CYP3A4 inducers may perhaps improve amount of diazepam elimination; consequently, efficacy of diazepam may very well be diminished.pentobarbital will lo